![]() ![]() H3R are mainly involved in blood–brain barrier function. H2R are involved in Th1 lymphocyte cytokine production. ![]() H1R are expressed in many cells, including mast cells, and are involved in Type 1 hypersensitivity reactions. Mast cells are multifunctional bone marrow-derived tissue-dwelling cells that are the major producer of histamine in the body. Histamine and its receptors (H1R–H4R) play a crucial and significant role in the development of various allergic diseases. 7Department of Biotechnology, Government of India, New Delhi, India.6Department of Dermatology and Allergy, Charité – Universitätsmedizin Berlin, Berlin, Germany.5Department of Pharmaceutical and Administrative Sciences, Western New England University, Springfield, MA, United States.4Central Food Technological Research Institute-Resource Centre, Lucknow, India.3Discipline of Biosciences and Biomedical Engineering (BSBE), Indian Institute of Technology Indore (IITI), Indore, Madhya Pradesh, India.2Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.1Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India. ![]()
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